Extremely low frequency electromagnetic field in combination with β-Lapachone up-regulates the genes of non-homologous end joining
نویسندگان
چکیده
منابع مشابه
Effects of extremely low-frequency electromagnetic field on expression levels of some antioxidant genes in human MCF-7 cells
In the past three decades, study on the biological effects of extremely low-frequency electromagnetic fields (ELF-EMFs) has been of interest to scientists. Although the exact mechanism of its effect is not fully understood, free radical processes has been proposed as a possible mechanism. This study was designed to evaluate the effect of 50-Hz EMFs on the mRNA levels of seven antioxidant genes ...
متن کاملModeling non-homologous end joining.
Non-homologous end joining (NHEJ) is an important DNA repair pathway for DNA double-strand breaks. Several proteins, including Ku, DNA-PKcs, Artemis, XRCC4/Ligase IV and XLF, are involved in the NHEJ for the DNA damage detection, DNA free end processing and ligation. The classical model of NHEJ is a sequential model in which DNA-PKcs is first recruited by the Ku bound DNA prior to any other rep...
متن کامل[Non-homologous DNA end joining].
DNA double strand breaks (DSB) are the most serious form of DNA damage. Repair of DSBs is important to prevent chromosomal fragmentation, translocations and deletions. Non-homologous end joining (NHEJ) is one of three major pathways for the repair of DSBs in human cells. In this process two DNA ends are joined directly, usually with no sequence homology, although in the case of same polarity of...
متن کاملThe Effects of Extremely Low Frequency Pulsed Electromagnetic Field on Biochemical Properties of the Prostate Cancer Cell Line, DU-145
Background: In the recent decades, there has been an increasing effort to study possible biological effects of extremely low frequency electromagnetic fields (ELF-EMFs). In this study, the effects of 50 Hz, 0.6 mT pulsed electromagnetic field on proliferation and biochemical properties, in a prostate cancer cell line, DU-145, and the simultaneous treatment of these cells with electromagnetic fi...
متن کاملThe Effects of Extremely Low Frequency Pulsed Electromagnetic Field on Collagen Synthesis of Rat Skin: a Biochemical and Histoligical Approach
The efficacious effects of pulsed electromagnetic field (PEMF) under the certain field parameters like frequency and the field intensity have been reported for various tissue and molecules. Since collagen is found abundantly in most tissue structures, this research was designed to further investigate the effects of extremely low frequency (ELF) PEMF on the synthesis of the epidermal collagen. ...
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2017
ISSN: 1110-8630
DOI: 10.1016/j.ejmhg.2017.05.003